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lifespan.io
Cellular Senescence
As your body ages, more of your cells become senescent. Senescent cells do not divide or support the tissues of which they are part; instead, they emit potentially harmful chemical signals, collectively known as the senescence-associated secretory phenotype (SASP), which encourages nearby cells to enter the same senescent state. Their presence ...
11 months ago
Senescence and Aging
3:16
Scientists Have Reached a Key Milestone in Learning How to Reverse Aging
TIME
Alice Park,Andrew. D Johnso
Jan 12, 2023
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Aging isn’t just about getting older—it’s about how well your cells function over time. Why do some people maintain boundless energy, sharp cognition, and resilient bodies well into old age, while others experience decline far too soon? It all comes down to the 12 hallmarks of aging—biological processes like DNA damage, mitochondrial dysfunction, inflammation, and cellular senescence that gradually erode health. But what if we could slow those processes down? When I interviewed @JulieGibsonClark
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Cellular senescence is one of the most powerful biological switches influencing aging, metabolic resilience, and disease progression. Decades of research have shown that senescent cells are not just “old cells”—they are metabolically and inflammatory active, reshaping the tissue environment through the SASP (senescence-associated secretory phenotype) and driving many chronic conditions we see in clinical practice. Cellular senescence can be initiated by several mechanisms, one of which is mitoch
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Nurturing molecular mechanisms like autophagy and countering cellular senescence holds significance. Yet, tangible clinical outcomes, like reduced mortality, take precedence. A case in point: weak glute muscles and myosteatosis increase COVID vulnerability. 🦠This highlights a core issue within the longevity realm. At the base of the pyramid lie behavior change and gradual resistance training. While not as flashy as intermittent fasting, they boast stronger supporting evidence! 💪📊#longevitysci
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