Background Intestinal fibrosis, a hallmark complication of Crohn’s disease (CD), frequently progresses to stricture formation and surgical intervention. Fibroblast metabolic reprogramming is important ...
On Wednesday, FibroBiologics, Inc. (NASDAQ: FBLG) submitted a new patent application with the U.S. Patent and Trademark Office (USPTO). The patent application covers a proprietary fibroblast-derived ...
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Senescent fibroblasts are aging cells in connective tissue that no longer divide and protect against tumor development. Yet, these same cells can promote cancer growth in a laboratory setting. Until ...
Cancer cells can brainwash their neighbors. Like the CIA deploying secret agents to turn an enemy, tumors use a similar strategy to manipulate nearby cells. The tumors’ agents are mitochondria, the ...
Scientists have mapped underappreciated scaffolding cells in skin, known as fibroblasts. They show for the first time how fibroblasts go 'rogue' in many different diseases affecting multiple organs – ...
Healing from any injury involves a delicate balance between scarring and inflammation — two processes that can wreak havoc as well as make repairs. When the injury is to the brain, the balance is that ...
NUDT21 regulates fibroblast senescence and is significantly decreased in aged and fibrotic lungs, impacting IPF progression. Alternative polyadenylation (APA) and NUDT21 downregulation enhance STAT3 ...
18 F-labeled fibroblast activation protein inhibitor tracer (18 F-FAPI-42) PET imaging can detect fibroblast activation in the myocardium among patients with dilated cardiomyopathy (DCM), according to ...
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