Calcium-activated chloride channels (CaCCs) play a pivotal role in a myriad of physiological processes. By responding to intracellular calcium concentration, these channels regulate epithelial ...
Structure of the calcium-activated chloride channel TMEM16A. The channel, which consists of two identical subunits, is shown in the center. The position of the membrane is indicated by lines. The ion ...
Biochemists have used cryo-electron microscopy to determine the detailed architecture of the chloride channel TMEM16A. This protein is a promising target for the development of effective drugs to ...
The TMEM16 family of membrane proteins was hailed as representing the elusive calcium-activated chloride channels. However, the majority of the family members turned out to be scramblases, proteins ...
Our laboratory uses a combination of cryo-electron microscopy, x-ray crystallography, and functional approaches to study the mechanisms of eukaryotic ion channels involved in calcium signaling and ...
Pant, S., Tam, S. W., & Long, S. B. (2025). The pentameric chloride channel BEST1 is activated by extracellular GABA. Proceedings of the National Academy of Sciences ...
It is vital to the regulation of cell activities through its role as a second messenger. Calcium signaling is the process whereby low cytoplasmic concentrations are deliberately increased to activate ...
The TMEM16 family of membrane proteins was hailed as representing the elusive calcium-activated chloride channels. However, the majority of the family members turned out to be scramblases, proteins ...
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