Murine mAbs were produced against purified microvillus membranes of rat colonocytes in order to establish a marker protein for this membrane. The majority of antibodies binding to the colonic ...

Microvillus inclusion disease (MVID) is a cause of chronic watery diarrhea that is attributed to a lack of nutrient absorption in the gastrointestinal tract in newborns. The disease can lead to ...

Intestinal microvilli, finger-like protrusions on the cell surface, are packed with the motor protein myosin-1a. This myosin was thought to serve a purely structural role, but now Vanderbilt cell ...

FRANKLIN SQUARE, Long Island (WABC) -- A family from Long Island is racing against the clock to find a cure for their son, who suffers from a rare genetic disease. Three-year-old Thomas Kevin Onorato ...

The major protein associated with actin in the microfilament core of intestinal microvilli has been purified. This protein, for which we propose the name villin, has a polypeptide molecular weight of ...

MVID is a life-threatening and ultra-rare autosomal recessive disease that affects newborns and children, leading to intestinal failure, significant morbidity and even death from severe secretory ...

In mice, deletion of the Rab8 protein disrupts organized molecular distribution to membranes of intestinal epithelial cells. Death by starvation follows, exactly as it does in humans with microvillus ...

Matthew Tyska, Ph.D., recalls being intrigued, from the first day of his postdoctoral fellowship in 1999, with a nearly 30-year-old photograph. It was an electron micrograph that showed the internal ...