Transmembrane proteins are essential for the survival and function of all living cells. They are involved in virtually every biological process, making them a vital target for drug development.
STEAP1 (Six-transmembrane epithelial antigen of the prostate 1), which was first found in prostate cancer, is a member of the STEAP protein family that is largely expressed in prostate epithelial ...
In silico antibody accessibility analysis indicates that ectodomain epitopes are transiently exposed, while MPER epitopes are virtually always occluded in the pre-fusion trimer.