Targeted protein degradation presents a promising strategy to address antimicrobial resistance, focusing on innovative ...

Targeted protein degradation has moved well beyond its prologue more than 20 years ago. 1 The number of publications describing different PROTACs (PROteolysis TArgeting Chimeras), molecular glues, and ...

Protein-degrader structure and function have been captured in unprecedented detail. Protein degraders are recognized as an exciting avenue for drug discovery and development, providing targeted ...

Targeted protein degradation (TPD) is transforming drug discovery by leveraging the cell’s natural protein disposal systems to eliminate disease-causing proteins. Innovators are making rapid and ...

Researchers developed nanotechnology that selectively binds and degrades abnormal proteins. The technology shows promise for ...

This article is based on a poster originally authored by Mat Calder, Ben Durham, Amy Prosser, Miguel Coelho, Aimee Blair, Jack Cobb, Marta Falcicchio, Ruben Alvarez Fernandez, Emma Ford, Alberto ...

Targeted protein degradation has opened up a new field of drug discovery with potential to treat previously ‘undruggable’ diseases Dundee researchers have revealed new levels of details of how protein ...

A Chinese research team has achieved a major advance in the precise regulation of protein degradation in living organisms, opening new avenues for therapeutic strategies against diseases ranging from ...

Targeted protein degradation (TPD) approaches including PROTAC and molecular glue have revolutionized drug discovery. However, in part due to complication of the ubiquitination and related ...

The company joins a group of degrader ADC (or DAC) developers that includes Bristol Myers Squibb and Pfizer.