Nature

Taming TLR4 may ease seizures

Activation of Toll-like receptors (TLRs) via a nuclear protein released from dying cells, high-mobility group box-1 (HMGB1) protein, leads to chronic epilepsy in rat models and in human epileptic ...
Nature

The effect of the accessory proteins, soluble CD14 and lipopolysaccharide-binding protein on Toll-like receptor 4 activity in human monocytes and adipocytes

There is a growinge body of evidence pointing towards an important role for Toll-like receptors (TLR) especially TLR4 in obesity and metabolic syndrome. Cell lysates (40 μg protein) were resolved, ...
ascopubs.org

Investigation of TLR4 and pSTAT3 expression on tumor and immune cells in the peripheral blood (PB) of patients with breast cancer (BC).

Association of genes copy number in extracellular DNA in patients with prostate cancer and sensitivity to radiotherapy. This is an ASCO Meeting Abstract from the 2021 ASCO Annual Meeting I. This ...
EurekAlert!

Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice ...

This new article publication from Acta Pharmaceutica Sinica B, discusses a fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist ...
News Medical

Research suggests toll-like receptor 4 appears to play role in severe COVID

The worldwide spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused the global coronavirus disease 2019 (COVID-19) pandemic. To date, this pandemic has infected over 207 ...