Neurodegenerative diseases, such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are medical conditions characterized by the progressive degradation ...
In most people with ALS, and many with FTD, cytoplasmic aggregates of TDP-43 plague degenerating neurons. What causes an RNA-binding protein that spends most of its time in the nucleus to pile up in ...
Different genetic mutations can converge on the same downstream pathology. The C9ORF72 repeat expansion and progranulin haploinsufficiency both trigger the RNA-binding protein TDP-43 to abandon the ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results