Although the pathophysiology of mesangial cells has long been considered to be the major factor in the development of glomerulosclerosis in type 1 or type 2 diabetes, more recent evidence suggests ...

Not intended for the UK Apecotrep (BI 764198) is a potential first-in-class, oral, selective TRPC6 inhibitor being investigated as a novel, ...

Diabetic kidney disease (DKD) is the most prevalent long-term complication of diabetes, affecting up to 30% of individuals with type 1 diabetes within the first 10 years of diagnosis.

Acute kidney injury (AKI) often occurs as a result of ischemia, which is a condition in which blood flow to part of the body is restricted, depriving tissues of oxygen and nutrients. This damage is ...

In its new incarnation, apecotrep has been shown to reduce protein in the urine (proteinuria) – a biomarker for kidney disease – in people with primary focal segmental glomerulosclerosis (FSGS), a ...

OTU deubiquitinase 5 (OTUD5) is a deubiquitinating enzyme that has been shown to play a key role in mediating innate immunity and inflammation development, and which is also involved in various ...

Vertex is running a phase 2 trial of inaxaplin in APOL1-mediated kidney diseases, including some forms of FSGS. The phase 3 ...

Cells expressing PAX8 (nucleus, red) considered podocyte precursors, line the outer Bowman’s capsule. Activated during the low salt-fasting mimicking diet (LS-FMD), the cells migrate and ...

Role of Ang II in Nephrin Expression and Podocyte Injury ...