Chronic liver disease gets worse when the liver's immune system stays overactive, resulting in ongoing inflammation and ...

The contractile responses of esophageal smooth muscle (SM) induced by platelet-activating factor (PAF) involve the activation of L-type voltage-dependent calcium channels (L-type VDCCs), ...

Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified an effective strategy to reduce structural liver damage and improve hepatic vascular function in cirrhosis. The ...

Eighty-eight patients were randomised and included in the study (BN 52021: 44; placebo: 44) and received at least one dose of the study medication (figure 1). These 88 patients were included in the ...

A research group led by Dr. Keisuke Obara, Dr. Kento Yoshioka, and Professor Yoshio Tanaka from the Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toho University, has ...

Heparin-induced thrombocytopenia (HIT) is an immune-mediated platelet disorder caused by antibodies that target complexes of platelet factor 4 (PF4) and heparin. HIT has been characterized as a ...

Experimental and clinical studies suggest that PAF antagonists like BN 52021 appear to be effective in cases of severe Gram-negative septic shock. [6] The outcome of the present multicentre study in ...