Are you ready for some late-season NFL drama? The NFL Week 16 schedule should provide it, with many teams fighting for NFL playoff berths and with several division leads on the line this week. The NFL Week 16 schedule could start with the game of the week.

This is probably one of the least interesting games of Week 16. The Saints are now 4-10 after playing spoiler the past two weeks against division rivals. The Jets, sitting at 3-11, still have a shot the top pick in the 2026 NFL Draft. Finally, I’ll be picking a home team to win. I’m going with New Orleans.

Colts quarterback Philip Rivers should face less pressure his second week back in the NFL, as his team plays the 49ers on "Monday Night Football."

That includes two marquee games that will hit us before Sunday. The Los Angeles Rams and Seattle Seahawks play what could be an NFC West title game when the two meet on Thursday Night Football. The Green Bay Packers look to shake off injuries to Micah Parsons and Christian Watson by sweeping their season series with the Chicago Bears on Saturday.

Get the opening NFL Week 16 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Dec. 18, 2025.