A new discovery may explain why so many people abandon cholesterol-lowering statins because of muscle pain and weakness.

The mechanism of skeletal muscle contraction is a process that relies on calcium signaling. However, the physiological role of calcium-induced calcium release (CICR) through the ryanodine receptor ...

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release. The ...

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these ...

Calcium is critical for bone health, optimal muscle activity, and other body processes such as blood clotting and heart function. How much calcium you need depends on your age and stage of life. Share ...