Almost every American has some degree of metabolic dysfunction — at least that’s what President Trump’s nominee for surgeon ...

The energy factories in our cells contain their own genes, and genetic mutations in them can cause deadly inherited diseases. These oblong-shaped organelles, or mitochondria, translate genes into ...

Saturday is Rare Disease Day, a day meant to shine a light on some of the more than 6,000 rare diseases that 300 million people around the world are diagnosed with. Kimberly Nicolas was diagnosed ...

Mitochondrial diseases are severe, often untreatable, and they leave human cells unable to grow normally without outside help. A new study published in Nature Metabolism now shows that a single gene ...

David Rand, a professor of natural history at Brown University, explains how studying mitochondria — the cell's energy producers — offers a useful way to understand complex gene-by-gene or ...

Prince Frederik of Luxembourg died from a genetic disease called PolG, but experts hope his passing could bring more awareness to the rare condition that impacted his life. Prince Frederik, 22, died ...

Serious damage to short-term kidney function—known as acute kidney injury, or AKI—can be fatal and also increase the risk of irreversible chronic kidney disease. It can be triggered by stressors ...

Rooted in malfunctions in the tiny power plants that energize our cells, mitochondrial disorders are notoriously complex and variable, with few effective treatments. Now, novel findings in microscopic ...

Constraint models have been extremely useful in identifying the deleterious variants that underlie disease in the part of the genome in the cell nucleus. However, nuclear constraint models could not ...

Multiple sclerosis (MS) affects an estimated 2.3 million people worldwide. Approximately 80% of people with MS have inflammation in the cerebellum, the part of the brain that helps control movement ...

For years, researchers have watched the tiny power plants inside brain cells falter in Parkinson’s disease and wondered what came first. Did those damaged mitochondria trigger the illness, or did they ...

NAD is a molecule found in every living cell of the body that plays an important role in creating energy in the body. Researchers from the University of Bergen, for the first time, show how ...