The major histocompatibility complex (MHC) represents a critical gene family in vertebrates that shapes immune recognition and disease resistance through its extraordinary allelic diversity.
The result is one molecule that can be both a checkpoint degrader and a cancer vaccine ( Nature 2026, DOI: 10.1038/s41586-025 ...
The anti-tumor immune response involves a series of complex steps mediated by various immune cells and signaling molecules.
The major histocompatibility complex (MHC) region plays a crucial role in immune function; therefore, any genetic or epigenetic polymorphisms within the MHC locus may result in various diseases, as ...
It is well known that the biggest genetic risk factor for the autoimmune disease systemic lupus erythematosus (SLE) is major histocompatibility complex class II (MHC-II). What remains unclear is the ...
Cattle possess a remarkable genetic diversity that underpins their adaptive immune responses and overall health. Central to this are the molecules encoded by the major histocompatibility complex (MHC) ...
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