Protein 'dark energy' provides insight into form vs. function in structure

Astronomers use the term dark energy to refer to energy in the universe that is unaccounted for by ordinary matter but ...
The Scientist

The Journey to a Nobel Prize: A Protein Design and Structure Research Timeline

In the wee hours of an October morning, David Baker, a protein biologist at the University of Washington (UW), received the most-awaited phone call in a scientist’s career. Halfway around the world, ...
Baylor College of Medicine

Surprising structure discovered in disordered protein

Inside each cell of the human body are proteins that control which genes are expressed at the right place and time. However, intriguingly, many of the most important proteins involved in gene ...
STAT

Protein structure competition, of AlphaFold fame, nearing deal to replace lost NIH funding

A three-decade-old competition that has spawned three Nobel laureates is becoming victim to the chaos at the National Institutes of Health. The Community Wide Experiment on the Critical Assessment of ...
Purdue University

Deep learning, 3D technology to improve structure modeling for protein interactions, create better drugs

WEST LAFAYETTE, Ind. – Proteins are often called the working molecules of the human body. A typical body has more than 20,000 different types of proteins, each of which are involved in many functions ...
STAT

Four years after AlphaFold’s AI ‘solved’ protein structure, a fierce competition lives on

In 2020, news headlines repeated John Moult’s words at the end of a stunning competition: Artificial intelligence had “solved” a long-standing grand challenge in biology, protein structure prediction.