Tau aggregation begins not in the cortex, but in the brainstem. Does tangle deposition in the locus coeruleus, which often starts in a person’s 30s, presage Alzheimer’s disease? In the September 22 ...

Andrew Luskin conducted research on the brain's peri-locus coeruleus neurons while he was a UW Medicine neuroscience Ph.D. student. A small cluster of cells deep within our brains, called the locus ...

A new study in Biological Psychiatry has linked signs of heightened arousal and reactivity -- a core symptom of posttraumatic stress disorder (PTSD) -- to overactivity of the locus coeruleus (LC), a ...

A restful night alternates in cycles between non-rapid eye movement (NREM) and rapid eye movement (REM) sleep states. The study from UNIL shows that a brain region called the "locus coeruleus" (in ...

The researchers also examined how brief bursts of locus coeruleus activation are influenced by background levels of locus coeruleus activity. This matters because locus coeruleus neurons operate in ...

Deep within the brainstem is a structure no bigger than a grain of rice, the locus coeruleus. The LC is often referred to as the “blue spot” because of a distinct blue pigment produced from its inner ...