Patients with serum ferritin levels higher than 1000 μg/L show a 91% increased risk for any fracture, with a doubled risk for vertebral and humerus fractures compared with those without iron overload.

Iron overload, characterized by elevated serum ferritin levels, has long been associated with various systemic complications, yet its impact on skeletal health has not been as well understood. A ...

BMP, bone morphogenetic protein; BMPR, bone morphogenetic protein receptor; HAMP, hepcidin; HFE, hereditary hemochromatosis protein; HJV, hemojuvelin; Holo-Tf, holo ...

This perspective argues that Parkinson’s disease may involve functional iron deficiency, where bioavailable iron is limited despite normal or elevated total iron in the brain. The authors propose that ...

Ferritin is a critical protein that serves as the primary storage form of iron in the body. This protein is fundamental for managing iron levels, which are essential for numerous physiological ...

Iron is essential for oxygen transport and energy metabolism, yet both deficiency and excess are linked to cardiovascular ...

Saturation of TfR1 leads to the dissociation of Hfe and the binding of the alter to the TfR2, which in turn influences the binding of BMP6 to its receptors on the membrane. Increased liver iron ...

Iron is one of the most essential minerals for your body however, did you know it can trigger Parkinson’s disease if not ...