Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results ...

Histamine is widely known for its role in allergic reactions but also functions as a key neurotransmitter in the brain, where ...

Researchers uncovered the role of the third intracellular loop in the G protein-coupled receptors' signaling mechanism, which could lead to a more targeted approach to drug discovery and a paradigm ...

FGFR1 is a receptor tyrosine kinase that drives multiple intracellular signaling pathways involved in tumor cell proliferation, survival and progression. Because these pathways are frequently ...

The nonapeptide Oxytocin is a cyclic nine-amino‐acid peptide that has long been studied for its possible roles in ...

The histamine H3 receptor typically becomes active upon binding to one of its agonists, such as histamine itself. This, in ...

A bitter taste receptor, TAS2R14, has been shown to respond to both extracellular and intracellular signals. Indeed, it can respond to both signals simultaneously. This finding is especially ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth, ...

Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen receptor alpha (mERα) signaling in specific cell types of female mice affects ...

The 8-Bromo-cAMP sodium salt PKA activator, a synthetic analog of cAMP, is one of the most potent tools of investigating and playing with this pathway, which has become an essential part of ...