eLife

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

CDK2-mediated TBK1 degradation via Dtx4 represents a previously unrecognized regulatory mechanism that modulates antiviral immunity in fish.
EurekAlert!

Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament

Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone formation in the spine, leading to severe neurological symptoms due to spinal ...
Medscape

Interferon-Driven Genes Signal Methotrexate Response in JIA

Higher baseline expression of interferon (IFN)-driven genes was tied to a better response to methotrexate in patients with juvenile idiopathic arthritis (JIA). Gene enrichment in the IFN-alpha (type I ...
News Medical

Interferon pathway activation identified as key driver in OPLL pathogenesis

Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone formation in the spine, leading to severe neurological symptoms due to spinal ...