You may print hundreds or even thousands of pages on your HP LaserJet printer between cartridge changes, so it's prudent to clean the unit whenever you change the toner cartridge to keep used toner ...
I have a NeXT 400dpi laser that uses the same Canon SX printing engine as the HP LaserJet II/III, Apple LaserWriter II series, etc., and never smell ozone when printing. I did when I first got it ...