GPCR dynamics, shown in purple as the human A 2A receptor, and elegant modifications in activation pathways (allostery) indicated by the blue arrow, are critical for enabling GPCRs to bind to multiple ...

About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane receptors called G protein-coupled receptors (GPCRs). GPCRs are indispensable for ...

Mutations in the GNAO1 gene can lead to severe neurological disorders, leading to treatment-resistant epilepsy, developmental delay and movement disorders in children. Zinc supplementation has emerged ...

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled ...

Septerna's Native Complex platform isolates GPCRs in their native form, enabling advanced drug discovery for previously undruggable targets, including oral small-molecule therapeutics. Lead molecule ...

Domain Therapeutics Rebrands as Kainova Therapeutics Advancing Its Clinical Pipeline of GPCR-Modulating Therapies -- Kainova Therapeutics rebrand reflects expanding capabilities powering next stage of ...

Many people are familiar with histamine, a biological molecule that serves as a key driver of allergic reactions and other ...

Chemerin is a key adipokine—a signaling protein released by adipose tissue—that regulates lipid metabolism and insulin sensitivity and thus is involved in many metabolic diseases such as obesity and ...