The authors further proceed to dissociate the interactions of FoxP3 with cofactors from its DNA-binding ability. While at least two of the hypomorphic mutants show attenuated binding to the genome, as ...

The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues. More than two decades ...

Regulatory T cells are specialized immune cells that suppress the immune response and prevent the body from attacking its own cells. Understanding how these cells work is key to determining how they ...

Thanks to regulatory T cells (Tregs), the immune system is kept in line via a careful system of checks and balances. Immune response too light? A viral infection spreads throughout the body. Immune ...

Researchers determined the Foxp3 protein is actually a cofactor, hijacking DNA-binding proteins responding to the immunological environment of the T cell. Based on the type of response needed, ...

Differentiation of multipotent precursor cells into distinct cell lineages is orchestrated by integration of cell-extrinsic cues, such as recognition of soluble or cell-bound ligands, growth factors, ...

Evaluating the Impact of Organizational Changes in Health Care Delivery: Challenges in Study Design FOXP3 expression in tumors was associated with worse overall survival probability and the risk ...

Scientists at the Salk Institute say they have discovered that the Foxp3 protein is essential for creating the unique chromatin architecture of regulatory T cells and, in turn, promoting their immune ...

Osaka, Japan – The immune system is tightly regulated to ensure that it only responds to actual health threats, instead of attacking our own bodies, which happens in cases of autoimmunity. Now, ...

A team of scientists from the Perelman School of Medicine at the University of Pennsylvania and Aum Biotech LLC have described the development of a novel cancer immunotherapy designed to target ...

IL-17-producing CD4⁺ T helper (Th17) cells have recently been defined as a unique subset of proinflammatory helper cells whose development depends on signaling initiated by IL-6 and TGF-β, autocrine ...