Osaka, Japan – The immune system is tightly regulated to ensure that it only responds to actual health threats, instead of attacking our own bodies, which happens in cases of autoimmunity. Now, ...
The immune system faces a delicate balancing act: it must be aggressive enough to fight infections and cancer, yet restrained enough to avoid attacking the body's own tissues. More than two decades ...
Mary E. Brunkow, Fred Ramsdell, and Dr. Shimon Sakaguchi were awarded the Nobel Prize in Physiology or Medicine 2025 for their groundbreaking discoveries concerning peripheral immune tolerance, which ...
Sakaguchi's 1995 discovery of regulatory T cells revealed a complex immune tolerance system beyond central tolerance. Brunkow and Ramsdell identified the Foxp3 gene mutation in 2001, linking it to ...
The Nobel Assembly at Karolinsky Institute has today decided to award the 2025 Nobel Prize in Physiology or Medicine jointly to Mary Branco, Fred Ramsdell, and Simonakaguchi for their discoveries ...
A team of scientists—including Jenny Umhoefer, seen here—uncover potential clues for future autoimmunity and cancer treatments by learning to fine-tune a gene that is centrally involved in regulating ...
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