One-fifth of patients in a phase 1 study responded to an investigational ERK inhibitor from Merck, bolstering hopes that this type of drug could be used effectively in combination with other cancer ...

Fluctuation in signal transduction pathways is frequently observed during mammalian development. However, its role in regulating stem cells has not been explored. Here we tracked spatiotemporal ERK ...

TASHKENT -- Uzbekistan's Erk (Freedom) Party, which was banned in the 1990s and its leader forced out of the country and his associates jailed, says it plans to try to field a candidate for president ...

RAMP1 protects against HIRI by inhibiting ERK and YAP phosphorylation signal transduction, highlighting its potential as a therapeutic target for HIRI and providing a new avenue for intervention.

G protein-coupled receptors (GPCRs) represent a diverse group of signaling proteins and are involved in a wide variety of physiological processes. Of particular importance to the pharmaceutical ...

A phase II study of sEphB4-HSA in metastatic castration-resistant prostate cancer (mCRPC). Background: Androgen deprivation therapy (ADT) is the backbone of therapy for metastatic hormone sensitive ...

The mitogen-activated protein kinase (MAPK) pathway integrates growth factor signaling through extracellular signal-regulated kinase (ERK) to control cell proliferation. To study ERK dynamics, many ...

The Erk (Freedom) Party says it will nominate a candidate to run in Uzbekistan’s October 24 presidential election. Erk was technically Uzbekistan’s first registered political party — having been ...

STATESBORO, GA (WTOC) - This fall's Erk Russell Classic will be a special one, as Erk Russell will be in attendance. As in two year old Erk, the great-grandson of the legendary Georgia Southern head ...