Retinoic acid suppresses immune defenses against cancer, but a new drug KyA33 boosts vaccine success and slows tumor growth ...

Scientists have uncovered how a vitamin A metabolite can suppress anti-cancer immunity. Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have uncovered new ...

EPFL researchers have successfully engineered cells of the immune system to more effectively recognize cancer cells. The work, covered in two papers, turns the previously lab-based method into a ...

MHC class II molecules are central to the adaptive immune response, serving as the means by which antigen-presenting cells, notably dendritic cells, display processed peptides to CD4+ T cells. This ...

Scientists at the Princeton University Branch of the Ludwig Institute for Cancer Research have identified novel mechanisms by ...

The immune cell repertoire is composed of many different cell types that are orchestrated in response to infection and other pathogens that enter the body. As a result, the body can defend itself ...

Cancer immunotherapy is a strategy that turns the patient’s own immune cells into a “search-and-destroy” force that attacks the tumor’s cells. The “search” immune cells are the dendritic cells, which ...

The immune system consists of inflammatory and regulatory T cells (Tregs) that promote or dampen immune activity, respectively. These cells react to specific antigens that specialized cells like ...

The Warburg effect describes how cancer cells switch from oxidative phosphorylation to glycolysis even in oxygen-rich ...

Cancer immunotherapy transforms a patient’s immune cells into a “search‑and‑destroy” force against tumors. But many cancers learn to camouflage themselves from dendritic cells—the immune system’s ...