Raf kinases are components of the MAP kinase pathway, a signal transduc-tion pathway that normally controls cell growth and division downstream of activated cell surface growth factor receptors. RAF1, ...

February 11, 2008 — Investigators have found that insulin-like growth factor binding protein 7 (IGFBP7), a secreted protein, dramatically influences the ability of an activating BRAF mutation to ...

ORLANDO, Florida (Reuters) - An experimental drug has shown promise as a treatment for advanced melanoma, one of the deadliest of cancers, according to preliminary results from a small trial presented ...

Researchers have uncovered a stealth survival strategy that melanoma cells use to evade targeted therapy, offering a promising new approach to improving treatment outcomes. The study, published in ...

LUT014 gel significantly reduces acne-like rashes from anti-EGFR therapies in colorectal cancer patients, improving quality of life. The phase 2 trial showed 70% improvement with high-dose gel, ...