Ion channels are attractive drug targets due to their importance in health and disease, but finding ways to target a specific ion channel selectively is a major challenge. Now, researchers have ...

BK channels (large-conductance, Ca2+-dependent K+ channels) are essential for the regulation of important biological processes such as smooth muscle tone and neuronal excitability. New research shows ...

Researchers have discovered a new mechanism for potassium channel inhibitor entry, which could improve the specificity of drugs targeting the channel. Upon binding to calcium ions, BK channels allow ...

A new study has unveiled a precise picture of how an ion channel found in most mammalian cells regulates its own function ...

A new study has unveiled a precise picture of how an ion channel found in most mammalian cells regulates its own function with a “ball-and-chain” channel-plugging mechanism, according to investigators ...