GEN

Re-Engineering the Drug Development Pipeline

Fail fast, fail cheap is a common clich in drug development. Studies project that anywhere from 4060% of potential drugs candidates fail in development due to absorption, distribution, metabolism, ...
Animal Welfare Institute

Stow, R., Kendrick, J., Ibbotson, N. et al. 2021. A new group housing approach for non-human primate metabolism studies. Journal of Pharmacological and Toxicological Methods ...

Understanding the absorption, distribution, metabolism and excretion (ADME) of candidate drugs in preclinical species is an integral part of the safety and efficacy evaluation in drug development. For ...
News Medical

Exploring a human multi-organ microphysiological system for preclinical oral bioavailability profiling

Absorption, distribution, metabolism, and excretion (ADME) are four main processes that demonstrate how a drug behaves after being administered. Therefore, ADME is key in defining a compound’s ...
Reading Eagle

Frontage Announces Full-Service Human Absorption, Metabolism, and Excretion (hAME) Studies with Radiolabeled Compounds at its Clinical Site in Secaucus, NJ

EXTON, Pa., April 6, 2021 /PRNewswire/ — Frontage Laboratories and Frontage Clinical Services are pleased to announce that we have developed the capability to perform full-service human Absorption, ...
Animal Welfare Institute

Kendrick, J., Stow, R., Ibbotson, N. et al. 2020. A novel welfare and scientific approach to conducting dog metabolism studies allowing dogs to be pair housed. Laboratory ...

Metabolism cages are designed to conduct absorption, distribution, metabolism and excretion (ADME) studies, enabling an ‘excretion balance’ scientific objective to be met. Historically, the design of ...
PharmiWeb

Thermo Fisher Scientific Launches Streamlined Workflow for Liver Cell Analysis

Thermo Fisher Scientific Launches Invitrogen™ TaqMan™ Cells-to-CT™ HepatoExpress Kit to Simplify Liver Cell Gene Expression and Help Advance Early-Stage Drug ...