Alternative RNA splicing tied to schizophrenia-like behaviors in animal models

In a new study, Chinese researchers have discovered the previously unrecognized role of alternative splicing of the DOC2A ...
Nature

Splicing controls the ubiquitin response during DNA double-strand break repair

Although evidence that splicing regulates DNA repair is accumulating, the underlying mechanism(s) remain unclear. Here, we report that short-term inhibition of pre-mRNA splicing by spliceosomal ...
Nature

Par-4/THAP1 complex and Notch3 competitively regulated pre-mRNA splicing of CCAR1 and affected inversely the survival of T-cell acute lymphoblastic leukemia cells

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of T-cell precursors. 1 The prostate apoptosis response factor-4 (Par-4) is a pro-apoptotic factor and induces apoptosis in ...